Re: Antidepressant puts newborns at risk, study says

[Steve]

sorry but I must plead ignorant. I guess you're too damn intelligent and
esoteric for me.

--
Steve


I love life...Yeah, I'm sad, but at the same time, I'm really happy that
something could make me feel that sad. It's like...It makes me feel alive,
you know. It makes me feel human. The only way I could feel this sad now is
if I felt something really good before. So I have to take the bad with the
good. So I guess what I'm feeling is like a beautiful sadness.

Trey Parker and Matt Stone, South Park, Raisins, 2003

> wrote in message
...
> On Thu, 10 Jun 2004 19:49:00 -0700, in alt.support.depression.medication
"jake"
> > wrote:
>
> :
> :"Steve" > wrote in message
> rs.com...
> :
> :
> :> everyone knows you shouldn't take AD's while pregnant.
> :
> :Sadly this is NOT the case...as a a mere glance in the pregnancy groups
> :would tell you..
> :
> :
> :> Are you just
> :> reminding us again and again for the hell of it?
> :
> :this is not a static group and women..epecially those under the influence
of
> :SSRIs
> :do need reminding of this and to beinformed of the latest research and
> :news...
> :for the babies sake..
> :
> :you have some weird objection to this?
> :
> :
> :>
> :> --
> :> Steve
>
>
> Yeah he's in love with a manic Jewish Celexa freak and new mom named
Naomi.

[Steve]

no it appears quite electrically charged in here. Especially when it comes
to this issue.

--
Steve


I love life...Yeah, I'm sad, but at the same time, I'm really happy that
something could make me feel that sad. It's like...It makes me feel alive,
you know. It makes me feel human. The only way I could feel this sad now is
if I felt something really good before. So I have to take the bad with the
good. So I guess what I'm feeling is like a beautiful sadness.

Trey Parker and Matt Stone, South Park, Raisins, 2003

> wrote in message
...
> On Fri, 11 Jun 2004 01:37:04 GMT, in alt.support.depression.medication
"Steve"
> > wrote:
>
> :everyone knows you shouldn't take AD's while pregnant. Are you just
> :reminding us again and again for the hell of it?
>
>
> Do you think this is a static group?

[jake]

"Steve" > wrote in message
.rogers.com...
> at times I object to you and the ever growing group of alarmists that seem
> to be sucking the life out of this NG. But, then again, I guess I'm just
> chirping in with my 2 cents like you seem so capable of doing on a regular
> basis. Oh I forgot. You have some kind of a inside scoop to the truth in
> here. Is the air different from you stand?

you have never seemed a stupid man to me..

since when are the facts of a matter "alarmist" or "suck the life out of a
group"?
this is a newsgroup concerned with anti-depressant medications not a club
for drug addicts to
engage in denial of basic facts..
particularly where infants are concerned... peddling self-serving lies and
nonsense is inexcusable..

the facts are that antidepressants put newborns at risk as the posters
subject line suggests ..
what possible motive can you have for objecting to this fact being made
known to the public as
the FDA's Pediatric Subcommittee wishes?

They met on WEDNESDAY to discuss this..
you cannot get MORE topical that that!!!

do you imagine THEY are "alarmists??????


on they contrary they reccomended NOT issuing a public advisory

mothers have a right to know..



http://www.fdaadvisorycommittee.com/FDC/AdvisoryCommittee/Committees/Anti-In
fective+Drugs/060904_pediatric/060904_SSRIneonatalR.htm

SSRI Antidepressant Pregnancy Exposure Risks Should Be Communicated In
Patient Labeling, Subcmte. Says

Antidepressant pregnancy exposure risks should be described in patient
labeling, FDA's Pediatric Subcommittee of its Anti-Infective Drugs Advisory
Committee recommended June 9.

"The point here is we've all been talking about giving the information out
to the doctors, and that's important, but you also have to give it to the
mother. The mothers have to have this information given to them the best
that they can have," subcommittee member Judith O'Fallon, PhD, Mayo Clinic,
said.

The subcommittee said that the potential risks of prenatal exposure to
selective serotonin and norepinephrine reuptake inhibitors should be
communicated to patients even though a conclusive link to toxicity has not
be determined.

FDA has received reports of neurological, neuromuscular and autonomic
effects in newborns whose mothers were taking SSRI/SNRIs such as Prozac,
Paxil, Celexa, Effexor, Zoloft and Luvox.

The side effects of agitation, irritability, trouble feeding etc. could be
the sign of a withdrawal syndrome, FDA said.

The subcommittee recommended against the issuance of a public health
advisory by FDA for fear that it would unduly scare patients away from
depression therapy based on inconclusive information.

The subcommittee also supported physician education as a means of
communicating the potential risks to newborns from SSRI/SNRIs but
recommended against the issuance of a letter to health care providers due to
the intricacies of the risk/benefit consideration involved.

FDA is proposing class labeling for SSRI/SNRIs on prenatal exposure be added
to the pregnancy section.

The proposed precaution states: "Neonates exposed to SSRI/SNRI late in 3rd
trimester have developed AE requiring prolonged hospitalization, respiratory
support, tube feeding. AE may arise immediately upon delivery."

Adverse events that have been reported include respiratory distress,
cyanosis, apnea, seizures, temperature instability, feeding difficulty,
vomiting, hypoglycemia, hypertonia, hyperreflexia, tremor, jitteriness,
irritability, and constant crying, the precaution will state.

The dosage and administration section may also advise tapering SSRI/SNRI
treatment late in the 3rd trimester, FDA said.

To watch an archived webcast of this meeting, click the button below. To
order videotapes & DVDs, email or call
800-627-8171.
Posted: Wednesday, June 09, 2004


http://www.iian.ibeam.com/events/fdcr001/index.jsp?ei={29B22469-CAEE-440E-BC
9E-207A859B302F}



>
> --
> Steve
>
>
> I love life...Yeah, I'm sad, but at the same time, I'm really happy that
> something could make me feel that sad. It's like...It makes me feel alive,
> you know. It makes me feel human. The only way I could feel this sad now
is
> if I felt something really good before. So I have to take the bad with the
> good. So I guess what I'm feeling is like a beautiful sadness.
>
> Trey Parker and Matt Stone, South Park, Raisins, 2003
>
> "jake" > wrote in message
> ...
> >
> > "Steve" > wrote in message
> > s.com...
> >
> >
> > > everyone knows you shouldn't take AD's while pregnant.
> >
> > Sadly this is NOT the case...as a a mere glance in the pregnancy groups
> > would tell you..
> >
> >
> > > Are you just
> > > reminding us again and again for the hell of it?
> >
> > this is not a static group and women..epecially those under the
influence
> of
> > SSRIs
> > do need reminding of this and to beinformed of the latest research and
> > news...
> > for the babies sake..
> >
> > you have some weird objection to this?
> >
> >
> > >
> > > --
> > > Steve
> > >
> > >
> > > I love life...Yeah, I'm sad, but at the same time, I'm really happy
that
> > > something could make me feel that sad. It's like...It makes me feel
> alive,
> > > you know. It makes me feel human. The only way I could feel this sad
now
> > is
> > > if I felt something really good before. So I have to take the bad with
> the
> > > good. So I guess what I'm feeling is like a beautiful sadness.
> > >
> > > Trey Parker and Matt Stone, South Park, Raisins, 2003
> > >
> > > > wrote in message
> > > ...
> > > > Antidepressant puts newborns at risk, study says
> > > >
> > > > Mary Vallis
> > > > National Post
> > > >
> > > >
> > > >
> > > > Taking the popular antidepressant Paxil while pregnant can harm
> newborn
> > > babies,
> > > > new Canadian research suggests.
> > > >
> > > > Doctors at Toronto's Hospital for Sick Children suspect babies can
> > suffer
> > > from
> > > > "discontinuation syndrome" -- withdrawal symptoms -- if their
mothers
> > used
> > > the
> > > > drug during the last three months of pregnancy.
> > > >
> > > > In their study, 12 babies born to 55 women who took Paxil during the
> > third
> > > > trimester suffered from complications in their first weeks of life,
> > > including
> > > > respiratory distress, hypoglycemia and jaundice. All of the babies
> > > recovered
> > > > within two weeks.
> > > >
> > > > On the other hand, only three babies of 54 born to a control group
> > endured
> > > > similar complications. Their mothers quit taking Paxil by the second
> > > trimester
> > > > or took another drug altogether.
> > > >
> > > > "This highly suggests that paroxetine [Paxil] exposure near term may
> > > compromise
> > > > fetal and natal health," said Dr. Adriana Costei, who presented the
> > > research at
> > > > the Pediatric Academic Societies annual meeting in Baltimore
> yesterday.
> > > >
> > > > "The fact that the adverse events were brief, without other
underlying
> > > > pathology, further supports drug exposure as the mechanism for the
> > adverse
> > > > effects."
> > > >
> > > > The solution may seem straightforward -- pregnant women should not
> take
> > > the drug
> > > > immediately before their due dates -- but the reality is much more
> > > complicated,
> > > > said Dr. Gideon Koren, the lead researcher and a professor of
> > pediatrics,
> > > > pharmacology and medicine at the University of Toronto.
> > > >
> > > > "The context is very serious," he said. "These are not conditions in
> > which
> > > you
> > > > can easily tell women to stop taking the drug."
> > > >
> > > > Women often take Paxil because they suffer from clinical depression.
> > > Switching
> > > > to another drug does not always ease their symptoms and quitting the
> > > treatment,
> > > > even for just a few months, can have dire consequences, Dr. Koren
> said.
> > > >
> > > > He referred to the case of Suzanne Killinger Johnson, the Toronto
> > > psychologist
> > > > who leaped in front of a Toronto subway train with her baby in her
> arms
> > > two
> > > > years ago. She had apparently stopped taking antidepressants because
> she
> > > feared
> > > > the medication could poison her son through her breast milk.
> > > >
> > > > Paxil belongs to a class of drugs called selective serotonin
reuptake
> > > inhibitors
> > > > (SSRIs) that also includes Zoloft and Prozac. They all work by
> adjusting
> > > the
> > > > amount of serotonin in a person's brain, but each drug has a
different
> > > > "half-life," meaning it stays in a person's body for a different
> length
> > of
> > > time.
> > > >
> > > > Paxil leaves the body more quickly than others and can "jolt" the
> > nervous
> > > system
> > > > if patients miss doses or suddenly stop their treatment. Past
studies
> > have
> > > shown
> > > > people taking Paxil suffer from withdrawal reactions more often than
> > > people
> > > > taking other SSRIs, Dr. Koren said.
> > > >
> > > > The babies' adverse complications are probably their version of
> > > withdrawal,
> > > > because the drug readily enters the placenta when a patient is
> pregnant,
> > > he
> > > > added.
> > > >
> > > > The researchers say their study is the first to link higher rates of
> > > perinatal
> > > > complications with Paxil.
> > > >
> > > > Three Canadian class actions have been filed against GlaxoSmithKline
> in
> > > the past
> > > > week alleging thousands of Paxil users suffered withdrawal reactions
> > when
> > > they
> > > > attempted to reduce or discontinue their daily doses of the drug,
and
> > that
> > > the
> > > > company failed to warn users of the drug's addictive nature. The
> > > allegations
> > > > have not yet been proven in court.
> > > >
> > > > A statement released yesterday by GlaxoSmithKline acknowledges
> > > discontinuation
> > > > symptoms may occur in some Paxil patients, but stresses they are
> usually
> > > mild,
> > > > short-lived and can be minimized by slowly reducing the dosage over
> > time.
> > > >
> > > > "Although animal studies have not shown any teratogenic or selective
> > > embryotoxic
> > > > effects, the safety of Paxil in human pregnancy has not been
> > established,"
> > > the
> > > > statement notes. "Paxil should not be used during pregnancy unless
the
> > > potential
> > > > benefit to the patient outweighs the possible risk to the fetus."
> > > >
> > > >
> > >
> > >
> >
> >
>
>