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aspartame (methanol, formaldehyde) toxicity: Murray 10.15.3 rmforall
aspartame (methanol, formaldehyde) toxicity: Murray 10.15.3 rmforall Rich Murray, MA Room For All 1943 Otowi Road, Santa Fe, New Mexico 87505 USA 505-986-9103 http://groups.yahoo.com/group/aspartameNM/message/1026 brief aspartame review: formaldehyde toxicity: Murray 9.11.3 rmforall http://google.com gives 221,000 websites for "aspartame" , with the top 9 of 10 listings being anti-aspartame, while http://groups.google.com finds on 700 MB of posts from 20 years of Usenet groups, 83,800 posts, the top 10 being anti-aspartame. http://news.google.com 8 recent aspartame items from 4500 sources. http://www.AllTheWeb.com gives 291,700, the top 7 of 10 being leading and very well informed volunteer anti-aspartame sites. http://teoma.com/index.asp gives 85,700 websites, top 8 of 10 anti. http://www.ncbi.nlm.nih.gov/PubMed lists 742 aspartame items. http://groups.yahoo.com/group/aspartameNM/message/989 EU votes 440 to 20 to approve sucralose, limit cyclamates & reevaluate aspartame & stevia: Murray 4.12.3 rmforall http://groups.yahoo.com/group/aspartameNM/message/1025 aspartame & formaldehyde toxicity: Murray 9.9.3 rmforall http://groups.yahoo.com/group/aspartameNM/messages for 1028 posts in a public searchable archive http://groups.yahoo.com/group/aspartame/messages 735 members http://groups.yahoo.com/group/aspartameNM/message/1024 aspartame review: methanol, formaldehyde, formic acid toxicity: Murray 9.5.3 rmforall http://groups.yahoo.com/group/aspartameNM/message/910 formaldehyde & formic acid from methanol in aspartame: Murray: 12.9.2 rmforall It is certain that high levels of aspartame use, above 2 liters daily for months and years, must lead to chronic formaldehyde-formic acid toxicity, since 11% of aspartame (1,120 mg in 2L diet soda, 5.6 12-oz cans) is 123 mg methanol (wood alcohol), immediately released into the body after drinking (unlike the large levels of methanol locked up in molecules inside many fruits), then quickly transformed into formaldehyde, which in turn becomes formic acid, both of which in time are partially eliminated as carbon dioxide and water. However, about 30% of the methanol remains in the body as cumulative durable toxic metabolites of formaldehyde and formic acid-- 37 mg daily, a gram every month. [Metabolism of aspartame in monkeys. Oppermann JA, Muldoon E, Ranney RE. J. Nutrition 1973 Oct; 103(10): 1454-1459.] If 10% of the methanol is retained as formaldehyde, that would give 12 mg daily formaldehyde accumulation, about 60 times more than the 0.2 mg from 10% retention of the 2 mg EPA daily limit for formaldehyde in water. Bear in mind that the EPA limit for formaldehyde in drinking water is 1 ppm, or 2 mg daily for a typical daily consumption of 2 L of water. http://groups.yahoo.com/group/aspartameNM/message/835 RTM: ATSDR: EPA limit 1 ppm formaldehyde in drinking water July 1999 5.30.2 rmforall This long-term low-level chronic toxic exposure leads to typical patterns of increasingly severe complex symptoms, starting with headache, fatigue, joint pain, irritability, memory loss, and leading to vision and eye problems, and even seizures. In many cases there is addiction. Probably there are immune system disorders, with a hypersensitivity to these toxins and other chemicals. http://groups.yahoo.com/group/aspartameNM/message/872 immune system reactions due to formaldehyde from the 11% methanol in aspartame: Thrasher: Tephly: Monte: Murray 9.27.2 rmforall J. Nutrition 1973 Oct; 103(10): 1454-1459. Metabolism of aspartame in monkeys. Oppermann JA, Muldoon E, Ranney RE. Dept. of Biochemistry, Searle Laboratories, Division of G.D. Searle and Co. Box 5110, Chicago, IL 60680 They found that about 70% of the radioactive methanol in aspartame put into the stomachs of 3 to 7 kg monkeys was eliminated within a day as carbon dioxide in exhaled air and as water in the urine. They did not mention that this meant that about 30% of the methanol must transform into formaldehyde and then into formic acid, much of which must remain as toxic products in all parts of the body. They did not report any studies on the distribution of radioactivity in body tissues, except that blood plasma proteins after 4 days held 4% of the initial methanol. This study did not monitor long-term use of aspartame. The low oral dose of aspartame and for methanol was 0.068 mmol/kg, about 1 part per million [ppm] of the acute toxicity level of 2,000 mg/kg, 67,000 mmol/kg, used by McMartin (1979). Two L daily use of diet soda provides 123 mg methanol, 2 mg/kg for a 60 kg person, a dose of 67 mmole/kg, a thousand times more than the dose in this study. By eight hours excretion of the dose in air and urine had leveled off at 67.1 +-2.1% as CO2 in the exhaled air and 1.57+-0.32% in the urine, so 68.7 % was excreted, and 31.3% was retained. [This data is the average of 4 monkeys.] http://groups.yahoo.com/group/aspartameNM/message/915 formaldehyde toxicity: Thrasher & Kilburn: Shaham: EPA: Gold: Murray: Wilson: CIIN: 12.12.2 rmforall Thrasher (2001): "The major difference is that the Japanese demonstrated the incorporation of FA and its metabolites into the placenta and fetus. The quantity of radioactivity remaining in maternal and fetal tissues at 48 hours was 26.9% of the administered dose." [Ref. 14-16] Arch Environ Health 2001 Jul-Aug; 56(4): 300-11. Embryo toxicity and teratogenicity of formaldehyde. [100 references] Thrasher JD, Kilburn KH. Sam-1 Trust, Alto, New Mexico, USA. http://www.drthrasher.org/formaldehy..._toxicity.html full text Confirming evidence and a general theory are given by Pall (2002): http://groups.yahoo.com/group/aspartameNM/message/909 testable theory of MCS type diseases, vicious cycle of nitric oxide & peroxynitrite: MSG: formaldehyde-methanol-aspartame: Martin L. Pall: Murray: 12.9.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/946 Functional Therapeutics in Neurodegenerative Disease Part 1/2: Perlmutter 7.15.99: Murray 1.10.3 rmforall http://groups.yahoo.com/group/aspartameNM/message/628 Rich Murray: Professional House Doctors: Singer: EPA: CPSC: formaldehyde toxicity 6.10.1 rmforall http://groups.yahoo.com/group/aspartameNM/message/782 RTM: Smith, Terpening, Schmidt, Gums: full text: aspartame, MSG, fibromyalgia 1.17.2 rmforall Jerry D Smith, Chris M Terpening, Siegfried OF Schmidt, and John G Gums Relief of Fibromyalgia Symptoms Following Discontinuation of Dietary Excitotoxins. The Annals of Pharmacotherapy 2001; 35(6): 702-706. Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA. BACKGROUND: Fibromyalgia is a common rheumatologic disorder that is often difficult to treat effectively. CASE SUMMARY: Four patients diagnosed with fibromyalgia syndrome for two to 17 years are described. All had undergone multiple treatment modalities with limited success. All had complete, or nearly complete, resolution of their symptoms within months after eliminating monosodium glutamate (MSG) or MSG plus aspartame from their diet. All patients were women with multiple comorbidities prior to elimination of MSG. All have had recurrence of symptoms whenever MSG is ingested. Siegfried O. Schmidt, MD Asst. Clinical Prof. Community Health and Family Medicine, U. Florida, Gainesville, FL Shands Hospital West Oak Clinic Gainesville, FL 32608-3629 352-376-5071 Debbie J. Hypes 304-872-4141 (Case # 1 of 4) P.O Box 25 Lookout, WV 25868-0025 She has about 1,000 on her local mailing list, and has been a volunteer activist since 1997. Her guide first came out in 1997: http://www.Pain-Free-Living.net "The Food Plan: How To Do It" $ 5 by mail, free by email. Her sister Darlene, now 47, cured her own severe fibromyalgia in 1995 by using an elimination diet, and then Debbie also cured herself by 1997. Their doctor, Siegfried Schmidt, paying attention, tried it on two more patients, who got well, and are his third and fourth cases. http://groups.yahoo.com/group/aspartameNM/message/846 RTM: aspartame in Merck Maxalt-MLT worsens migraine, AstraZeneca Zomig, Eli Lilly Zyprexa, J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab, Pfizer Cool Mint Listerine Pocketpaks 7.16.2 rmforall Migraine MLT-Down: an unusual presentation of migraine in patients with aspartame-triggered headaches. Newman LC, Lipton RB Headache 2001 Oct; 41(9): 899-901. [Merck 10-mg Maxalt-MLT, for migraine, has 3.75 mg aspartame, while 12 oz diet soda has 200 mg.] Headache Institute, St. Lukes-Roosevelt Hospital Center, New York, NY Department of Neurology Albert Einstein College of Medicine, Bronx, NY Innovative Medical Research http://groups.yahoo.com/group/aspartameNM/message/855 RTM: Blumenthall & Vance: aspartame chewing gum headaches Nov 1997 7.28.2 rmforall Harvey J. Blumenthal, MD, Dwight A Vance, RPh Chewing Gum Headaches. Headache 1997 Nov-Dec; 37(10): 665-6. Department of Neurology, University of Oklahoma College of Medicine, Tulsa, USA. Aspartame, a popular dietetic sweetener, may provoke headache in some susceptible individuals. Herein, we describe three cases of young women with migraine who reported their headaches could be provoked by chewing gum sweetened with aspartame. [6-8 mg aspartame per stick chewing gum] http://groups.yahoo.com/group/aspartameNM/message/925 aspartame puts formaldehyde adducts into tissues, Part 1/2 full text, Trocho & Alemany 6.26.98: Murray 12.22.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/926 aspartame puts formaldehyde adducts into tissues, Part 2/2 full text, Trocho & Alemany 6.26.98: Murray 12.22.2 rmforall http://ww.presidiotex.com/barcelona/index.html Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X, Fernandez-Lopez JA, Alemany M ["Trok-ho"] Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Sci 1998 Jun 26; 63(5): 337-49. Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain. http://www.presidiotex.com/barcelona/index.html Maria Alemany, PhD (male) http://groups.yahoo.com/group/aspartameNM/message/864 Murray: Butchko, Tephly, McMartin: Alemany: aspartame formaldehyde adducts in rats 9.8.2 rmforall Prof. Alemany vigorously affirms the validity of the Trocho study against criticism: Butchko, HH et al [24 authors], Aspartame: review of safety. Regul. Toxicol. Pharmacol. 2002 April 1; 35 (2 Pt 2): S1-93, review available for $35, [an industry paid organ]. Butchko: "When all the research on aspartame, including evaluations in both the premarketing and postmarketing periods, is examined as a whole, it is clear that aspartame is safe, and there are no unresolved questions regarding its safety under conditions of intended use." [ They repeatedly pass on the ageless industry deceit that the methanol in fruits and vegetables is as as biochemically available as that in aspartame-- see the 1984 rebuttal by Monte, below. In the same report, Schiffman concludes on page S49, not citing any research after 1997, "Thus, the weight of the scientific evidence indicates that aspartame does not cause headache." Dr. Susan S. Schiffman, Dept. of Psychiatry, Duke University 919-684-3303, 660-5657 http://groups.yahoo.com/group/aspartameNM/message/864 Murray: Butchko, Tephly, McMartin: Alemany: aspartame formaldehyde adducts in rats 9.8.2 rmforall ] http://groups.yahoo.com/group/aspartameNM/message/911 RTP ties to industry criticized by CSPI: Murray: 12.9.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/622 Rich Murray: Gold: Koehler: Walton: Van Den Eeden: Leon: aspartame toxicity 6.4.1 rmforall four double-blind studies http://groups.yahoo.com/group/aspartameNM/message/623 Rich Murray: Simmons: Gold: Schiffman: Spiers: aspartame toxicity 6.4.1 rmforall two double-blind studies http://www.holisticmed.com/aspartame...2-response.htm Mark Gold exhaustively critiques European Commission Scientific Committee on Food re aspartame (12.4.2): 59 pages, 230 references http://groups.yahoo.com/group/aspartameNM/message/957 safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF: Murray 1.12.3 rmforall EU Scientific Committee on Food, a whitewash http://groups.yahoo.com/group/aspartameNM/message/1018 aspartame toxicity coverup increases danger of corporate meltdown: Michael C. Carakostas of Coca-Cola: Murray 8.11.3 rmforall http://www.isrtp.org/new_members/members1.htm The International Society of Regulatory Toxicology and Pharmacology Carakostas, Michael C., DVM, PhD Director/Scientific & Regulatory Affairs The Coca-Cola Company PO Drawer 1734 Atlanta, GA 30301 T. 404/676-4234 F. 404/676-7166 E-mail: http://www2.coca-cola.com/ourcompany...aspartame.html [photo] Aspartame: The world agrees it's safe By Michael Carakostas, DVM, PhD Director, Scientific and Regulatory Affairs, Coca-Cola It is commendable that Carakostas mentions the core problem, albeit disparagingly: "During digestion, aspartame yields a very small amount of methanol-- as do many other food substances. The body converts this methanol to formaldehyde, which is instantly converted to formate. Formate is quickly eliminated as carbon dioxide and water." Plenty of evidence in the mainstream scientific literature since 1973 shows that as much as 30% of the formaldehyde is retained in the body as toxic, cumulative adducts to the DNA, RNA, and proteins in all cells and tissues, leading to pointed reports by informed doctors and experts. Clearly, there are no safe levels for chronic, low-level formaldehyde exposure. If just 10% of the methanol from six cans of diet soda is retained in the body as toxic products of formaldehyde and formic acid, that is sixty times the EPA limit for allowable formaldehyde from daily drinking water. http://groups.yahoo.com/group/aspartameNM/message/1016 President Bush & formaldehyde (aspartame) toxicity: Ramazzini Foundation carcinogenicity results Dec 2002: Soffritti: Murray 8.3.3 rmforall p. 88 "The sweetening agent aspartame hydrolyzes in the gastrointestinal tract to become free methyl alcohol, which is metabolized in the liver to formaldehyde, formic acid, and CO2. (11)" Medinsky MA & Dorman DC. 1994; Assessing risks of low-level methanol exposure. CIIT Act. 14: 1-7. Ann N Y Acad Sci. 2002 Dec; 982: 87-105. Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats. Soffritti M, Belpoggi F, Lambertin L, Lauriola M, Padovani M, Maltoni C. Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was administered to 50 male and 50 female Sprague-Dawley rats beginning at six weeks of age at concentrations of 2,500, 1,500, 500, 250, 50, or 0 mg/L. Animals were kept under observation until spontaneous death. Formaldehyde and acetaldehyde were found to produce an increase in total malignant tumors in the treated groups and showed specific carcinogenic effects on various organs and tissues. PMID: 12562630 http://groups.yahoo.com/group/aspartameNM/message/934 24 recent formaldehyde toxicity [Comet assay] reports: Murray 12.31.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/935 Comet assay finds DNA damage from sucralose, cyclamate, saccharin in mice: Sasaki YF & Tsuda S Aug 2002: Murray 1.1.3 rmforall [Also borderline evidence, in this pilot study of 39 food additives, using test groups of 4 mice, for DNA damage from for stomach, colon, liver, bladder, and lung 3 hr after oral dose of 2000 mg/kg aspartame-- a very high dose.] http://groups.yahoo.com/group/aspartameNM/message/961 genotoxins, Comet assay in mice: Ace-K, stevia fine; aspartame poor; sucralose, cyclamate, saccharin bad: Y.F. Sasaki Aug 2002: Murray 1.27.3 rmforall [A detailed look at the data] http://www.dorway.com/tldaddic.html 5-page review Roberts HJ Aspartame (NutraSweet) addiction. Townsend Letter 2000 Jan; http://www.sunsentpress.com/ Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416 800-814-9800 561-588-7628 561-547-8008 fax http://groups.yahoo.com/group/aspartameNM/message/669 1038-page medical text "Aspartame Disease: An Ignored Epidemic" published May 30 2001 $ 60.00 postpaid data from 1200 cases available at http://www.amazon.com over 600 references from standard medical research http://www.dorway.com David O. Rietz over 12,000 print pages Mission-Possible-USA Betty Martini 770-242-2599 http://www.dorway.com/asprlink.html many links http://www.dorway.com/nslawsuit.txt Jeff Martin, Attorney http://www.dorway.com/doctors.txt What many informed doctors are saying/have said about aspartame http://www.HolisticMed.com/aspartame 603-225-2100 Aspartame Toxicity Information Center Mark D. Gold 12 East Side Drive #2-18 Concord, NH 03301 http://www.holisticmed.com/aspartame.../methanol.html "Scientific Abuse in Aspartame Research" Aspartame Consumer Safety Network and Pilot Hotline [1987-2001] Mary Nash Stoddard, Founder & President P.O. Box 780634 Dallas, TX 75378 . 214-352-4268 http://web2.airmail.net/marystod/index.html http://web2.airmail.net/marystod/espanol.htm Toxicology Sourcebook: "Deadly Deception: Story of Aspartame" http://groups.yahoo.com/group/aspartameNM/message/802 RTM: 700.club.com: CBN: Totheroh & Robertson: aspartame expose 2.13.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/805 RTM: Ive: UK Daily Mirror Magazine: aspartame toxicity 2.18.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/857 RTM: www.dorway.com: original documents and long reviews of flaws in aspartame toxicity research 7.31.2 rmforall http://www.dorway.com/upipart1.txt http://groups.yahoo.com/group/aspartameNM/message/262 aspartame expose 96K Oct 1987 Part 1/3: Gregory Gordon, UPI reporter: Murray 7.10.0 rmforall http://www.dorway.com/enclosur.html http://groups.yahoo.com/group/aspartameNM/message/53 aspartame history Part 1/4 1964-1976: Gold: Murray 11.6.9: rmforall http://groups.yahoo.com/group/aspartameNM/message/927 Rumsfeld, 1977 head of Searle Corp., got aspartame FDA approval: Turner: Murray 12.23.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/928 revolving door, Monsanto, FDA, EPA: NGIN: Murray 12.23.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/957 safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF: Murray 1.12.3 rmforall EU Scientific Committee on Food http://groups.yahoo.com/group/aspartameNM/message/841 RTM: Merisant Co., MSD Capital, Dell Computer Corp., NutraSweet Co., JW Childs Assc.: aspartame-neotame toxicity 7.10.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/876 hyperthyroidism (Graves disease) in George and Barbara Bush, 1991-- aspartame toxicity? Roberts 1997: Murray 10.9.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/874 re "dry drunk": Bisbort: danger to President Bush from aspartame toxicity: Murray: 2.24.2 9.29.2 rmforall Many scientific studies and case histories report: * headaches * many body and joint pains (or burning, tingling, tremors, twitching, spasms, cramps, stiffness, numbness, difficulty swallowing) * fever, fatigue, swollen glands * "mind fog", "feel unreal", poor memory, confusion, anxiety, irritability, depression, mania, insomnia, dizziness, slurred speech, sexual problems, poor vision, hearing (deafness, tinnitus), or taste * red face, itching, rashes, hair loss, burning eyes or throat, dry eyes or mouth, mouth sores, burning tongue * obesity, bloating, edema, anorexia, poor appetite or excessive hunger or thirst * breathing problems, shortness of breath * nausea, diarrhea or constipation * coldness * sweating * racing heart, low or high blood pressure, erratic blood sugar levels * hypothryroidism or hyperthyroidism * seizures * birth defects * brain cancers * addiction * aggrivates diabetes, autism, allergies, lupus, ADHD, fibromyalgia, chronic fatigue syndrome, multiple chemical sensitivity, multiple sclerosis, and interstitial cystitis (bladder pain). ************************************************** ********* http://www.readthelabel.org.uk/ Additives Survivors' Network (UK) Geoff Brewer http://www.chem.ox.ac.uk/mom/aspartame/aspartame.html http://www.chm.bris.ac.uk/webproject...ers/sarah.html Sarah Rogers http://www.react.ie/Health/Nutrition/Aspartame.htm Ireland http://members.tripod.com/~mission_p...nd_branch.html http://www.aspartame.ca/indexa.html John T. Linnell http://www.cybernaute.com/earthconce...taMalcache.htm http://www.fedupwithfoodadditives.info/ Australia FAILSAFE diet http://www.bradymax.com/nzaa/ New Zealand http://www.reseauproteus.net/therapi.../aspartame.htm France http://ww2.grn.es/avalls/aspa1.htm Spain http://www.geocities.com/HotSprings/Falls/8669/ Brazil http://www.phd.com.br/aspartame.htm http://hem.passagen.se/mission.possible.sweden/ http://home.online.no/~dusan/foods/aspartame.html Norway http://www.ostara.org/aspartam/#menue Germany http://www.aspartaam.nl/info/product.html Holland, in Dutch http://www.laleva.org/ Italy 9 languages http://www.laleva.cc/alimenti/alimenti.html aspartame vs stevia 4.17.03 http://users.westnet.gr/~cgian/aspartame.htm Greece http://www.cseindia.org/html/cola-indepth/index.htm India ************************************************** ********* http://groups.yahoo.com/group/aspartameNM/message/870 Aspartame: Methanol and the Public Interest 1984: Monte: Murray 9.23.2 rmforall Dr. Woodrow C. Monte Aspartame: methanol, and the public health. Journal of Applied Nutrition 1984; 36 (1): 42-54. (62 references) Professsor of Food Science [retired 1992] Arizona State University, Tempe, Arizona 85287 The methanol from 2 L of diet soda, 5.6 12-oz cans, 20 mg/can, is 112 mg, 10% of the aspartame. The EPA limit for water is 7.8 mg daily for methanol (wood alcohol), a deadly cumulative poison. Many users drink 1-2 L daily. The reported symptoms are entirely consistent with chronic methanol toxicity. (Fresh orange juice has 34 mg/L, but, like all juices, has 16 times more ethanol, which strongly protects against methanol.) "Fruit and vegetables contain pectin with variable methyl ester content. However, the human has no digestive enzymes for pectin (6, 25) particularly the pectin esterase required for its hydrolysis to methanol (26). Fermentation in the gut may cause disappearance of pectin (6) but the production of free methanol is not guaranteed by fermentation (3). In fact, bacteria in the colon probably reduce methanol directly to formic acid or carbon dioxide (6) (aspartame is completely absorbed before reaching the colon). Heating of pectins has been shown to cause virtually no demethoxylation; even temperatures of 120 deg C produced only traces of methanol (3). Methanol evolved during cooking of high pectin foods (7) has been accounted for in the volatile fraction during boiling and is quickly lost to the atmosphere (49). Entrapment of these volatiles probably accounts for the elevation in methanol levels of certain fruit and vegetable products during canning (31, 33)." Recent research [see links at end of post] supports his focus on the methanol to formaldehyde toxic process: "The United States Environmental Protection Agency in their Multimedia Environmental Goals for Environmental Assessment recommends a minimum acute toxicity concentration of methanol in drinking water at 3.9 parts per million, with a recommended limit of consumption below 7.8 mg/day (8). This report clearly indicates that methanol: "is considered a cumulative poison due to the low rate of excretion once it is absorbed. In the body, methanol is oxidized to formaldehyde and formic acid; both of these metabolites are toxic." (8).... Recently the toxic role of formaldehyde (in methanol toxicity) has been questioned (34). No skeptic can overlook the fact that, metabolically, formaldehyde must be formed as an intermediate to formic acid production (54). Formaldehyde has a high reactivity which may be why it has not been found in humans or other primates during methanol poisioning (59).... If formaldehyde is produced from methanol and does have a reasonable half life within certain cells in the poisoned organism the chronic toxicological ramifications could be grave. Formaldehyde is a known carcinogen (57) producing squamous-cell carcinomas by inhalation exposure in experimental animals (22). The available epidemiological studies do not provide adequate data for assessing the carcinogenicity of formaldehyde in man (22, 24, 57). However, reaction of formaldehyde with deoxyribonucleic acid (DNA) has resulted in irreversible denaturation that could interfere with DNA replication and result in mutation (37)...." http://www.dorway.com/barua.html Dr. J. Barua (ophthalmic surgeon), Dr. Arun Bal (surgeon) Emerging facts about aspartame. Journal Of The Diabetic Association Of India 1995; 35 (4): (79 references) "...the total amount of methanol absorbed will be approximately 10% of aspartame ingested. An EPA assessment of methanol states that methanol, 'is considered a cumulative poison due to the low rate of excretion once it is absorbed. The absorbed methanol is then slowly converted to formaldehyde...'" "Reaction of formaldehyde with DNA has been observed, by spectrophotometry and electron microscopy, to result in irreversible denaturation." "DKP [from aspartame] has been implicated in the occurence of brain tumors." ************************************************** ********** http://groups.yahoo.com/group/aspartameNM/message/939 aspartame (aspartic acid, phenylalanine) binding to DNA: Karikas July 1998: Murray 1.5.3 rmforall Karikas GA, Schulpis KH, Reclos GJ, Kokotos G Measurement of molecular interaction of aspartame and its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7. Dept. of Chemistry, University of Athens, Greece http://www.chem.uoa.gr "K.H. Schulpis" "G.J. Reclos" http://groups.yahoo.com/group/aspartameNM/message/960 aspartame & MSG: possible role in autoimmune hepatitis: Prandota Jan 2003: Murray 1.15.3 rmforall Roberts, Hyman J., 1924- , Useful insights for diagnosis, treatment and public heath: an updated anthology of original research, 2002, 798 pages, Palm Beach Institute for Medical Research, Inc. P.O. Box 17799, West Palm Beach, FL 33416 fax 561-547-8008 aspartame disease pages 627-685, 778-780 http://groups.yahoo.com/group/aspartameNM/message/859 RTM: Roberts: the life work of a brilliant clinician: aspartame toxicity 8.2.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/790 RTM: Moseley: review Roberts "Aspartame Disease: An Ignored Epidemic" 2.7.2 rmforall http://groups.yahoo.com/group/aspartameNM/message/858 RTM: Samuels: Strong: Roberts: Gold: flaws in double-blind studies re aspartame and MSG toxicity 8.1.2 rmforall "Survey of aspartame studies: correlation of outcome and funding sources," 1998, unpublished: http://www.dorway.com/peerrev.html Walton found 166 separate published studies in the peer reviewed medical literature, which had relevance for questions of human safety. The 74 studies funded by industry all (100%) attested to aspartame's safety, whereas of the 92 non-industry funded studies, 84 (91%) identified a problem. Six of the seven non-industry funded studies that were favorable to aspartame safety were from the FDA, which has a public record that shows a strong pro-industry bias. Ralph G. Walton, MD, Prof. of Clinical Psychology, Northeastern Ohio Universities, College of Medicine, Dept. of Psychiatry, Youngstown, OH 44501, Chairman, The Center for Behavioral Medicine, Northside Medical Center, 500 Gypsy Lane, P.O. Box 240 Youngstown, OH 44501 330-740-3621 http://www.neoucom.edu/DEPTS/Psychiatry/walton.htm http://groups.yahoo.com/group/aspartameNM/message/938 aspartame harms mice brain cells: Hetle & Eltervaag: 2001 thesis abstract: Sonnewald 1995 study, full text: Murray 1.5.3 rmforall http://groups.yahoo.com/group/aspartameNM/message/346 WebMD: Barclay: Barth: survey shows aspartame hurts memory in students 11.9.00 http://www.psy.tcu.edu/psy/barth.htm Timothy M. Barth Department of Psychology Texas Christian University TCU Box 298920 Fort Worth, TX 76129 Chairman, Physiological Psychology 817-921-7410 http://groups.yahoo.com/group/aspartameNM/message/760 Kovatsi L, Tsouggas M The effect of oral aspartame administration on the balance of magnesium in the rat. Magnes Res 2001 Sep;14(3): 189-94. Laboratory of Forensic Medicine & Toxicology, Faculty of Medicine Aristotle University of Thessaloniki, Greece http://groups.yahoo.com/group/aspartameNM/message/943 aspartame, cell phones, brain cancer July 1999 Hardell: Murray 1.9.3 rmforall http://www.medscape.com/MedGenMed/braintumors Lennart Hardell, M.D., PhD, in 1999 reported in Sweden that both cell phone use and heavy aspartame use correlate with increased brain cancers +46 19 602 15 46 http://groups.yahoo.com/group/aspartameNM/message/31 Murray: Wurtman: aspartame & seizures 11.9.85 10.30.99 Wurtman RJ Aspartame: possible effect on seizure susceptibility. Lancet 1985 Nov 9; 2(8463): 1060. Richard J. Wurtman, Ph.D. 617-253-3091 Professor of Neuroscience Prof. of Health Sciences and Technology Massachusetts Institute of Technlogy Cambridge, Mass. 02139 http://groups.yahoo.com/group/aspartameNM/message/32 Murray: Drake: aspartame & panic attacks 9.13.86 10.30.99 rmforall Miles E. Drake, MD Panic attacks and excessive aspartame ingestion. Lancet 1986 Sep 13; 2(8507): 631. Department of Neurology and Psychiatry, Ohio State University Medical Center, Columbus, Ohio 43210, USA http://www.truthinlabeling.org/ Truth in Labeling Campaign [MSG] Adrienne Samuels, PhD The toxicity/safety of processed free glutamic acid (MSG): a study in suppression of information. Accountability in Research 1999; 6: 259-310. 52-page review P.O. Box 2532 Darien, Illinois 60561 858-481-9333 http://www.msgmyth.com/ Debby Anglesey Battling the "MSG Myth", A Survival Guide and Cookbook - $19.00 P.O. Box 895 Richland, WA 99352 509-735-3397 http://groups.yahoo.com/group/aspartameNM/message/97 Lancet website aspartame letter 7.29.99: Excitotoxins 1999 Part 1/3 Blaylock: Murray 1.14.0 rmforall The Medical Sentinel Journal 1999 Fall; (95 references) http://www.dorway.com/blayenn.html Russell L. Blaylock, MD 601-982-1175 Madison, Mississippi "Excitotoxins: The Taste that Kills", 1977, 298 p., 493 references. "Health and Nutrition Secrets that can save your life", 2002, 459 p., 558 + 30 references, $ 30 http://www.russellblaylockmd.com/ George R. Schwartz, MD "In Bad Taste: The MSG Syndrome", 1988 http://www.healthpress.com/ PO Box 37470 Albuquerque, NM 87176 505-888-1394 Kathleen Frazier, Publisher http://groups.yahoo.com/group/aspartameNM/message/841 RTM: Merisant Co., MSD Capital, Dell Computer Corp., NutraSweet Co., JW Childs Assc.: aspartame-neotame toxicity 7.10.2 rmforall ************************************************** ************** http://www.vegsource.com extensive vegan information http://www.vegsource.com/articles/kradjian_milk.htm Robert Kradjian MD Discusses Milk http://groups.yahoo.com/group/aspartameNM/message/971 Joel Fuhrman critique of Atkins diet in "Eat To Live": Murray 3.1.3 rmforall Substitute stevia (at health food stores). Avoid all products with aspartame and MSG. Gradually reduce alcohol, caffeine (coffee, cocoa, and teas), meat, fish, eggs, milk, butter, and cheese, food additives and colors, fluoride, city water. Enjoy organic rice, beans, nuts, almond butter, vegetables, fruits, with modest use of soy products and sprouted grain breads, flax seed and olive oils, and fill your jugs with deionized water. ************************************************** *************** |
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